Nebido 1000Mg 4Ml Solution For Injection Summary

After the administration of radio-labelled testosterone, about 90% of the radioactivity appears in the urine as glucuronic and sulphuric acid conjugates and 6% appears in the faeces after undergoing enterohepatic circulation. Following intramuscular administration of this depot formulation the release rate is characterised by a half life of 90± 40 https://fikom.unisba.ac.id/2025/01/21/proviron-25-mg-multi-pharm-an-overview/ days. Athletes treated for testosterone replacement in primary and secondary male hypogonadism should be advised that the medicinal product contains an active substance which may produce a positive reaction in anti-doping tests.

Testosterone Undecanoate contains benzyl benzoate

Prior to testosterone initiation, all patients must undergo a detailed examination in order to exclude a risk of pre-existing prostatic cancer. Local guidelines for safety monitoring under testosterone replacement therapy should be taken into consideration. Testosterone replacement therapy for male hypogonadism when testosterone deficiency has been confirmed by clinical features and biochemical tests (seesection 4.4). Because it’s so slow in terms of its effects, you don’t have to go overboard when it comes to using Nebido. You can get away with using 1,000 mg every 12 weeks, and after the first six weeks, you can get away with one more 1,000 mg dose just to add some space in-between the gap. Because it’s so slow acting and combined with its potency, only a few injections of it will yield tremendous benefits.

Nebido Administration and Uses:

This is usually done in the ventrogluteals, deltoid, or another dense muscle area. The Nebido type of injection is very strong and will last for a while, making it more convenient to use Nebido injections than some other types of TRT injections. Male hormones may increase the development of prostate cancer and the growth of benign prostate gland (benign prostatic hypertrophy).

• Therefore, testosterone replacement therapy should be used with caution in these patients.
• Testosterone undecanoate is a prodrug of testosterone and is an androgen and anabolic–androgenic steroid (AAS).
• Nebido is not indicated for use in children and adolescents and it has not been clinically evaluated in males under 18 years of age (see section 4.4).
• If prescription or Please inform your doctor or pharmacist if you are currently using any prescription medication or have recently used it.

Testosterone Undecanoate comes in packs of 1 vial with 4 ml solution for injection. Special care will be taken to avoid injection into a blood vessel (see “Administrati­on ”). The most common side effects are acne and pain where the injection is given. The solution for intramuscular injection is to be visually inspected prior to use and only clear solutions free from particles should be used. Treatment with high doses of testosterone preparations commonly may reversibly stop or reduce sperm production (see also under “Possible side effects” ).

Your doctor will measure your blood testosterone levels before starting treatment and during the early stages of treatment. Your doctor may give you the second injection after only six weeks in order to quickly reach the necessary testosterone level. Your doctor will inject Nebido (1 ampoule / vial) very slowly into a muscle. This is enough to maintain sufficient testosterone levels without leading to a build-up of testosterone in the blood. Testosterone replacement therapy for male hypogonadism when testosterone deficiency has been confirmed by clinical features and biochemical tests (see section 4.4). There are no studies undertaken to demonstrate the efficacy and safety of this medicinal product in patients with renal or hepatic impairment.

There are 5AR inhibitors that can be taken, but because most of the androgenic side effects aren’t as serious, most men typically ignore these kinds of side effects. With any hormone that involves androgen receptors, there is always going to be the risk of estrogenic effects. This is because that whenever you introduce testosterone, they will aromatize, meaning that they interact with the aromatase enzyme, which converts them into estrogen. This interaction is very important to make note of because, in other circumstances, you’re going to need an AI (aromatase inhibitor) to lower the overall levels of your estrogen by shutting down the activity of the enzyme altogether. But in other instances, a SERM (selective estrogen receptor modulator) is going to act to prevent the estrogen from binding to receptor sites by acting as a buffer.

The muscle serves as a depot for the sustained release of testosterone into the systemic circulation. Serum testosterone levels should be measured before start and during initiation of treatment. Depending on serum testosterone levels and clinical symptoms, the first injection interval may be reduced to a minimum of 6 weeks as compared to the recommended range of 10 to 14 weeks for maintenance. With this loading dose, sufficient steady state testosterone levels may be achieved more rapidly.

As with all oily solutions, Nebido must be injected strictly intramuscularly and very slowly (over two minutes). Pulmonary microembolism of oily solutions can in rare cases lead to signs and symptoms such as cough, dyspnoea, malaise, hyperhidrosis, chest pain, dizziness, paraesthesia, or syncope. These reactions may occur during or immediately after the injection and are reversible. The patient should therefore be observed during and immediately after each injection in order to allow for early recognition of possible signs and symptoms of pulmonary oily microembolism. Treatment is usually supportive, e.g. by administration of supplemental oxygen. Pulmonary microembolism of oily solutions can in rare cases lead to signs and symptoms such as cough, dyspnoea, malaise, hyperhidrosis, chest pain, dizziness, paraesthesia, or syncope.

Each ampoule / vial with 4 ml solution for injection contains 1000 mg testosterone undecanoate corresponding to 631.5 mg testosterone. It is important that you stay in communication with your medical professionals and you notify them if you are having any negative side effects. The delivery method is what makes Nebido injections such an effective way to raise testosterone in the body. The reason for this is the fact that injections are the most direct route to get testosterone in the bloodstream. In a Nebido injection, you’ll find that the injection site creates a natural reservoir of testosterone that slowly disperses throughout the weeks to provide an evenly-balanced treatment that won’t fizzle out after a few days. Fatty fluid NEBIDO® can reach the lungs (pulmonary microembolics of oily solutions) and in rare cases may cause symptoms such as coughing, difficulty in breathing, general unwellness, excessive sweating, chest pain, dizziness, tingling or fainting.